CYP2E1 and ALD

CYP2E1*5B, CYP2E1*6, CYP2E1*7B, CYP2E1*2, and CYP2E1*3 allele frequencies in iranian populations.

BACKGROUND CYP2E1 encodes an enzyme which is mainly involved in bioactivation of potential carcinogens such as N-nitrosamines. Polymorphisms in the gene have been reported to be associated with cancer. The aim of this study was to evaluate genotype distributions and allele frequencies of five CYP2E1 polymorphisms in Iran. MATERIALS AND METHOD Two hundred healthy individuals of an Iranian popu...

Ald Ebaran: Users's Manual

Increased bioaccumulation of urethane in CYP2E1-/- versus CYP2E1+/+ mice.

Urethane is a fermentation by-product and a potent animal carcinogen. Human exposure to urethane occurs through consumption of alcoholic beverages and fermented foods. Recently, CYP2E1 was identified as the primary enzyme responsible for the metabolism of [(14)C]carbonyl-labeled urethane. Subsequently, attenuation of urethane-induced cell proliferation and genotoxicity in CYP2E1-/- mice was rep...

Increased bioaccumulation of Urethane in CYP2E1-/- vs. CYP2E1+/+ Mice

Urethane is a fermentation by-product and a potent animal carcinogen. Human exposure to urethane occurs through consumption of alcoholic beverages and fermented foods. Recently, CYP2E1 was identified as the primary enzyme responsible for the metabolism of C-carbonyl-labeled urethane. Subsequently, attenuation of urethaneinduced cell proliferation and genotoxicity in CYP2E1-/mice was reported. P...

Alcoholic Liver Disease (ALD)

Liver disease related to alcohol (Ethanol, ethyl alcohol) is very common global problem and is one of the major medical complications of alcohol abuse. Daily consumption is usual for causation of liver disease. Intake of alcohol is measured as one unit. Each unit contains 8 gm of ethanol and variable in various common beverages, e.g. 1/2 pint of beer, 1 measure of spirit, 1 glass wine or sherry...